CD200 is a transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. It contains an Ig-like domain like V and an Ig-like domain like C2 in its extracellular domain. CD200 is widely expressed but not ubiquitous. Its receptor (CD200R) is restricted mainly to mast cells, basophils, macrophages, and dendritic cells, suggesting that myeloid cell regulation is the main function of CD200. CD200 and CD200R associate through their respective N-terminal Ig-like domains.
In myeloid cells, CD200R initiates inhibitory signals after receptor-ligand contact. In T cells, CD200 functions as an independent costimulatory molecule of the CD28 pathway. Furthermore, CD200 also plays an important role in preventing graft rejection, autoimmune diseases, and miscarriages.
Manufacturer: Bon Opus
Proteins Neuroscience Neural lineage markers
Type: recombinant proteins
Specific against: human
Quantity: 1 mg
Item No: C311-1 mg
eClass 6.1: 34160400
eClass 9.0: 42020190
Expression: Human cells
- Lyophilized protein should be stored at <-20 ° C, although stable at room temperature for 3 weeks.
- The reconstituted protein solution can be stored at 4-7C for 2-7 days.
- Aliquots of reconstituted samples are stable at <-20 ° C for 3 months.
Lyophilized from a 0.2 µm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
Membrane glycoprotein OX-2, CD200, MOX1, MOX2
Recombinant human CD200 is produced by our mammalian expression system and the target gene encoding Gln31-Gly232 is expressed with a 6His tag at the C-terminus.
The information and documents presented (manual, product data sheet, and safety data sheet) correspond to our latest update and should serve for guidance purposes only. We do not guarantee timeliness. We kindly ask you to make a request for specific requirements, if necessary.